Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study.

ABSTRACT:

Background

Oxidative stress and inflammation are considered to be important pathways leading to particulate matter (PM)-associated disease. In this exploratory study, we examined the effects of metals and oxidative potential (OP) in urban PM on biomarkers of systemic inflammation, oxidative stress and neural function.

Methods

Fifty-three healthy non-smoking volunteers (mean age 28 years, twenty-eight females) were exposed to coarse (2.5-10 μm, mean 213 μg/m³), fine (0.15-2.5 μm, 238 μg/m³), and/or ultrafine concentrated ambient PM (<0.3 μm, 136 μg/m³). Exposures lasted 130 min, separated by ≥2 weeks. Metal concentrations and OP (measured by ascorbate and glutathione depletion in synthetic airway fluid) in PM were analyzed. Blood and urine sam

SUBMITTER: Liu L 

PROVIDER: S-EPMC6396878 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature