Confined growth of multiple gold nanorices in dual-mesoporous silica nanospheres for improved computed tomography imaging and photothermal therapy.

ABSTRACT:

Introduction

In this work, we have developed a novel "confined-growth" strategy to synthesize PEGylated multiple gold nanorices-encapsulated dual-mesoporous silica nanospheres (designated as PEGylated MGNRs@DMSSs) containing both small mesopores (2.5 nm) in the shell and large mesopores (21.7 nm) in the core based on a well-established, seed-mediated growth method. The photothermal effect and CT imaging ability were also studied.

Methods

The nanoparticles were characterized by Fourier transform infrared (FT-IR) spectra, N₂ absorption isotherms, Field-emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Inductively coupled plasma atomic emission spectroscopy (ICP-AES) and Confocal microscopy.

Results

The longitudinally-loca

SUBMITTER: Qin L 

PROVIDER: S-EPMC6396883 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature