SNR analysis of contrast-enhanced MR imaging for early detection of rheumatoid arthritis.

ABSTRACT:

Objective

To investigate whether signal to noise (SNR) analysis of contrast-enhanced MRI gives additional benefit for early disease detection by Magnetic Resonance Imaging (MRI) of experimental rheumatoid arthritis (RA) in a small animal model.

Methods

We applied contrast-enhanced MRI at 7T in DBA mice with or without collagen-induced arthritis (CIA). Clinical score, OMERACT RAMRIS analysis and analysis of signal to noise ratios (SNR) of regions of interest in RA bearing mice, methotrexate/methylprednisolone acetate treated RA and control animals were compared with respect to benefit for early diagnosis.

Results

While treated RA and control animals did not show signs of RA activity in any of the above-mentioned scoring methods at any time point analyzed, RA animals re

SUBMITTER: Gassert FT 

PROVIDER: S-EPMC6396898 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature