Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration.

ABSTRACT: Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and dynein motors play additional roles in peripheral nerve regeneration is not well understood. Here we use genetic mutants of motor proteins in a zebrafish peripheral nerve regeneration model to visualize and define in vivo roles for kinesin and dynein. We find that both kinesin-1 and dynein are required for zebrafish peripheral nerve regeneration. While loss of kinesin-1 reduced the overall robustness of axonal regrowth, loss of dynein dramatically impaired axonal regeneration and also reduced injury-induced Schwann cell remodeling. Chimeras

SUBMITTER: Ducommun Priest M 

PROVIDER: S-EPMC6396928 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature