Succinate links atrial dysfunction and cardioembolic stroke.

ABSTRACT:

Objective

To determine whether altered metabolic profiles represent a link between atrial dysfunction and cardioembolic (CE) stroke, and thus whether underlying dysfunctional atrial substrate may contribute to thromboembolism risk in CE stroke.

Methods

A total of 144 metabolites were measured using liquid chromatography-tandem mass spectrometry in plasma samples collected within 9 hours of stroke onset in 367 acute stroke patients. Stroke subtype was assigned using the Causative Classification of Stroke System, and CE stroke (n = 181) was compared to non-CE stroke (n = 186). Markers of left atrial dysfunction included abnormal atrial function (P-wave terminal force in lead V1, PTFV₁ >4,000 μV·ms), left atrial enlargement on echocardiography, and frank atrial fibri

SUBMITTER: Nelson SE 

PROVIDER: S-EPMC6396969 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature