Postmortem neurodegenerative markers and trajectories of decline in cognitive systems.

ABSTRACT:

Objective

To assess whether neurodegenerative pathologies are differentially related to trajectories of change in different cognitive abilities.

Methods

At annual intervals for up to 21 years, 915 older participants in a longitudinal clinical-pathologic cohort study completed a battery of 15 tests from which previously established composite measures of episodic memory, semantic memory, working memory, and perceptual speed were derived. At death, they underwent a neuropathologic examination to quantify Alzheimer disease pathology, Lewy bodies, transactive response DNA-binding protein 43 (TDP-43) pathology, and hippocampal sclerosis plus multiple markers of cerebrovascular disease. Time-varying effect models were used to assess change over time in the relation of neuropatholog

SUBMITTER: Wilson RS 

PROVIDER: S-EPMC6396970 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature