Genetic architecture of hippocampal subfields on standard resolution MRI: How the parts relate to the whole.

ABSTRACT: The human hippocampus can be subdivided into subfields with unique functional properties and differential vulnerability to disease or neuropsychiatric conditions. Identifying genes that confer susceptibility to such processes is an important goal in developing treatments. Recent advances in automatic subfield segmentation from magnetic resonance images make it possible to use these measures as phenotypes in large-scale genome-wide association studies. Such analyses are likely to rely largely on standard resolution (~1 mm isotropic) T₁ -weighted images acquired on 3.0T scanners. Determining whether the genetic architecture of subfields can be detected from such images is therefore an important step. We used Freesurfer v6.0 to segment hippocampal subfields in two large twin studie

SUBMITTER: Elman JA 

PROVIDER: S-EPMC6397064 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature