Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort.

ABSTRACT: Objectives To identify factors predicting maternal sex steroid hormone concentrations in early pregnancy. Methods The Infant Development and the Environment Study recruited healthy pregnant women from academic medical centers in four US cities. Gold standard liquid chromatography-tandem mass spectrometry was used to measure maternal sex steroids concentrations (total testosterone [TT], free testosterone [FT], estrone [E1], estradiol [E2], and estriol [E3] concentrations) in serum samples from 548 women carrying singletons (median = 11.7 weeks gestation). Women completed questionnaires on demographic and lifestyle characteristics. Results In multivariable linear regression analyses, hormone concentrations varied in relation to maternal age, body mass index (BMI), race, and parity. Older mot

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC6397082 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature