TBA225, a fusion toxoid vaccine for protection and broad neutralization of staphylococcal superantigens.

ABSTRACT: Superantigens (SAgs) play a major role in the pathogenesis of Staphylococcus aureus and are associated with several diseases, including food poisoning, bacterial arthritis, and toxic shock syndrome. Monoclonal antibodies to these SAgs, primarily TSST-1, SEB and SEA have been shown to provide protection in animal studies and to reduce clinical severity in bacteremic patients. Here we quantify the pre-existing antibodies against SAgs in many human plasma and IVIG samples and demonstrate that in a major portion of the population these antibody titers are suboptimal and IVIG therapy only incrementally elevates the anti-SAg titers. Our in vitro neutralization studies show that a combination of antibodies against SEA, SEB,and TSST-1 can provide broad neutralization of staphylococcal SAgs. We rep

SUBMITTER: Venkatasubramaniam A 

PROVIDER: S-EPMC6397225 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature