Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis.

ABSTRACT: Heart failure is a worldwide leading cause of death. Diet and obesity are particularly of high concern in heart disease etiology. Gravely, altered nutrition during developmental windows of vulnerability can have long-term impact on heart health; however, the underlying mechanisms are poorly understood. In the understanding of the initiation of chronic diseases related to developmental exposure to environmental challenges, deregulations in epigenetic mechanisms including micro-RNAs have been proposed as key events. In this context, we aimed at delineating the role of micro-RNAs in the programming of cardiac alterations induced by early developmental exposure to nutritional imbalance. To reach our aim, we developed a human relevant model of developmental exposure to nutritional imbalance by

SUBMITTER: Siddeek B 

PROVIDER: S-EPMC6397280 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature