Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.

ABSTRACT: The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychiatric disorder. Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. To determine the role of glucocorticoid signalling in the hindbrain we have developed a no

SUBMITTER: Gannon AL 

PROVIDER: S-EPMC6397323 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature