A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.

ABSTRACT: Cigarette smoke exposure is the leading modifiable risk factor for chronic obstructive pulmonary disease (COPD); however, the clinical and pathologic consequences of chronic cigarette smoke exposure are variable among smokers. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of COPD. Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT_5-8 microsatellite repeat) ( rs5844572 ). The role of this polymorphim in mediating disease susceptibility to COPD-related traits remains unknown. We performed a cross-sectional analysis of DNA samples from 641 subjects to analyze MIF-794 CATT_5-8 ( rs5844572 ) polymorphism by standard methods. We generated multivariable logistic regr

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6397351 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature