Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney.

ABSTRACT: Hypokalemia contributes to the progression of chronic kidney disease, although a definitive pathophysiological theory to explain this remains to be established. K⁺ deficiency results in profound alterations in renal epithelial transport. These include an increase in salt reabsorption via the Na⁺-Cl^- cotransporter (NCC) of the distal convoluted tubule (DCT), which minimizes electroneutral K⁺ loss in downstream nephron segments. In experimental conditions of dietary K⁺ depletion, punctate structures in the DCT containing crucial NCC-regulating kinases have been discovered in the murine DCT and termed "WNK bodies," referring to their component, with no K (lysine) kinases (WNKs). We hypothesized that in humans, WNK bodies occur in hypokale

SUBMITTER: Thomson MN 

PROVIDER: S-EPMC6397373 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature