Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn²⁺ transporter.

ABSTRACT: Zinc (Zn²⁺) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn²⁺ deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn²⁺ is nephrotoxic. As for other ions and solutes, Zn²⁺ is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn²⁺ import. Renal regulation of Zn²⁺ is of particular interest in light of growing evidence that Zn²⁺ may play a role in kidney stone formation. The objective of this study was to

SUBMITTER: Landry GM 

PROVIDER: S-EPMC6397374 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature