In silico simulations of occurrence of transcription factor binding sites in bacterial genomes.

ABSTRACT:

Background

Interactions between transcription factors and their specific binding sites are a key component of regulation of gene expression. Until recently, it was generally assumed that most bacterial transcription factor binding sites are located at or near promoters. However, several recent works utilizing high-throughput technology to detect transcription factor binding sites in bacterial genomes found a large number of binding sites in unexpected locations, particularly inside genes, as opposed to known or expected promoter regions. While some of these intragenic binding sites likely have regulatory functions, an alternative scenario is that many of these binding sites arise by chance in the absence of selective constraints. The latter possibility was supported by in silico si

SUBMITTER: Mrazek J 

PROVIDER: S-EPMC6397444 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature