Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development.

ABSTRACT:

Background

Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a large protein ring that binds DNA strands by encircling them. In addition to this central role in chromosome segregation, cohesin is also needed for DNA repair, gene transcription regulation and chromatin architecture. Though mutations in both cohesin and cohesin-regulator genes have been identified in many human cancers, the contribution of cohesin to cancer development is still under debate.

Methods

Normal mucosa, early adenoma, and carcinoma samples deriving from 16 subjects affected by colorectal cancer (CRC) were analyzed by OncoScan for scoring both chr

SUBMITTER: Sarogni P 

PROVIDER: S-EPMC6397456 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature