FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis.

ABSTRACT:

Background

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are limited. Previous studies have suggested a beneficial role of FTY720, a sphingosine 1-phosphate (S1P) receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes, in the treatment of experimental autoimmune neuritis (EAN). Therefore, we investigated whether FTY720 is also beneficial in chronic experimental autoimmune neuritis (c-EAN), a recently developed rat model mimicking human CIDP.

Methods

c-EAN was induced in Lewis rats by immunization with S-palm P0(180-199) peptide. Ra

SUBMITTER: Kremer L 

PROVIDER: S-EPMC6397476 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature