Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.

ABSTRACT: Staphylococcus aureus is a notorious human bacterial pathogen with considerable capacity to develop antibiotic resistance. We have observed that human infections caused by highly drug-resistant S. aureus are more prolonged, complicated, and difficult to eradicate. Here we describe a metabolic adaptation strategy used by clinical S. aureus strains that leads to resistance to the last-line antibiotic, daptomycin, and simultaneously affects host innate immunity. This response was characterized by a change in anionic membrane phospholipid composition induced by point mutations in the phospholipid biosynthesis gene, cls2, encoding cardiolipin synthase. Single cls2 point mutations were sufficient for daptomycin resistance, antibiotic treatment failure, and pers

SUBMITTER: Jiang JH 

PROVIDER: S-EPMC6397524 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature