Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells.

ABSTRACT: In their natural habitat of rotting fruit, the nematode Caenorhabditis elegans feeds on the complex bacterial communities that thrive in this rich growth medium. Hundreds of diverse bacterial strains cultured from such rotting fruit allow C. elegans growth and reproduction when tested individually. In screens for C. elegans responses to single bacterial strains associated with nematodes in fruit, we found that Rhizobium causes a genome instability phenotype; we observed abnormally long or fragmented intestinal nuclei due to aberrant nuclear division, or defective karyokinesis. The karyokinesis defects were restricted to intestinal cells and required close proximity between bacteria and the worm. A genetic screen for C. elegans mutations that cause the sam

SUBMITTER: Kniazeva M 

PROVIDER: S-EPMC6397575 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature