Infiltration of CD8⁺ T cells into tumor cell clusters in triple-negative breast cancer.

ABSTRACT: Infiltration of [Formula: see text] T lymphocytes into solid tumors is associated with good prognosis in various types of cancer, including triple-negative breast cancer (TNBC). However, the mechanisms underlying different infiltration levels are largely unknown. Here, we have characterized the spatial profile of [Formula: see text] T cells around tumor cell clusters (tightly connected tumor cells) in the core and margin regions in TNBC patient samples. We found that in some patients, the [Formula: see text] T cell density first decreases when moving in from the boundary of the tumor cell clusters and then rises again when approaching the center. To explain various infiltration profiles, we modeled the dynamics of T cell density via partial differential equations. We spatially modulated th

SUBMITTER: Li X 

PROVIDER: S-EPMC6397588 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature