Molecular control of macroscopic forces drives formation of the vertebrate hindgut.

ABSTRACT: The embryonic gut tube is a cylindrical structure from which the respiratory and gastrointestinal tracts develop¹. Although the early emergence of the endoderm as an epithelial sheet^2,3 and later morphogenesis of the definitive digestive and respiratory organs^4-6 have been investigated, the intervening process of gut tube formation remains relatively understudied^7,8. Here we investigate the molecular control of macroscopic forces underlying early morphogenesis of the gut tube in the chick embryo. The gut tube has been described as forming from two endodermal invaginations-the anterior intestinal portal (AIP) towards the rostral end of the embryo and the caudal intestinal portal (CIP) at the caudal end-that migrate towards one another, internalizi

SUBMITTER: Nerurkar NL 

PROVIDER: S-EPMC6397660 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature