MiR-192-5p Silencing by Genetic Aberrations Is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features.

ABSTRACT: Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular carcinoma (HCC), but little is known about the implications of heterogeneity and shared molecular networks within the CSC population. Through miRNA profile analysis in an HCC cohort (n = 241) for five groups of CSC⁺ HCC tissues, i.e., EpCAM⁺, CD90⁺, CD133⁺, CD44⁺, and CD24⁺ HCC, we identified a 14-miRNA signature commonly altered among these five groups of CSC⁺ HCC. miR-192-5p, the top-ranked CSC miRNA, was liver-abundant and -specific and markedly downregulated in all five groups of CSC⁺ HCC from two independent cohorts (n = 613). Suppressing miR-192-5p in HCC cells significantly increased multiple CSC popul

SUBMITTER: Gu Y 

PROVIDER: S-EPMC6397664 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature