Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma.

ABSTRACT:

Purpose

Unique cells characterized by multipotency, self-renewal, and high tumorigenic potential have been recently discovered in mucoepidermoid carcinomas. These cells are defined by high aldehyde dehydrogenase activity and high CD44 expression (ALDH^highCD44^high) and function as cancer stem cells (CSC). It has been recently shown that p53 regulates cell differentiation, suggesting that induction of p53 by therapeutic blockade of the MDM2-p53 interaction may constitute a novel strategy to ablate CSCs. Here, we evaluated the effect of a small-molecule inhibitor of MDM2-p53 interaction (MI-773) on the fraction of CSCs in mucoepidermoid carcinoma.

Experimental design

Human mucoepidermoid carcinoma cells (UM-HMC-1,-3A,-3B) were used to assess the effect of

SUBMITTER: Andrews A 

PROVIDER: S-EPMC6397688 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature