KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.

ABSTRACT: Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell properties. In mouse melanomas, both CD34⁺p75^- (CD34⁺) and CD34^-p75^- (CD34^-) tumor subpopulations were characterized as melanoma-propagating cells (MPC) that exhibit some of those key features. However, these two subpopulations differ from each other in tumorigenic potential, ability to recapitulate heterogeneity, and chemoresistance. In this study, we demonstrate that CD34⁺ and CD34^- subpopulations carrying the BRAF^V600E mutation confer differential sensitivity to targeted BRAF inhibition. Through elevated KDM5B expression, melanoma

SUBMITTER: Liu X 

PROVIDER: S-EPMC6397704 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature