Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.

ABSTRACT:

Background

The lethal-7 (let-7) family members and their targets are involved in the development and progression of tumors. Let-7-related polymorphisms have been reported to be associated with tumorigenesis and prognosis. In gastric cancer, however, the related studies are limited.

Aim

To investigate the role of let-7-related microRNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population.

Methods

A total of 898 gastric cancer patients and 992 tumor-free controls were recruited into this study from 2008 to 2013. Gastric cancer patients were followed periodically. Ten single nucleotide polymorphisms (SNPs) in the let-7 gene region or their target mRNAs were genotyped using the MassARRAY system and their as

SUBMITTER: Jia ZF 

PROVIDER: S-EPMC6397727 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature