Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study.

ABSTRACT: Manganese enhanced magnetic resonance imaging (MEMRI) has been previously used to determine the effect of acute cocaine on calcium-dependent synaptic activity in male rats. However, there have been no MEMRI studies examining sex differences in the functional neural circuits affected by repeated cocaine. In the present study, we used MEMRI to investigate the effects of repeated cocaine on brain activation in female and male rats. Adult female and male rats were scanned at 4.7 Tesla three days after final treatment with saline, a single cocaine injection (15 mg kg^-1, i.p. × 1 day) or repeated cocaine injections (15 mg kg^-1, i.p. × 10 days). A day before imaging rats were provided with an i.p. injection of manganese chloride (70 mg kg^-1). Cocaine produced effe

SUBMITTER: Perez PD 

PROVIDER: S-EPMC6397741 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature