Pain severity as a mediator of the association between depressive symptoms and physical performance in knee osteoarthritis.

ABSTRACT:

Objective

Depressive symptoms in knee osteoarthritis (OA) are associated with increased pain severity and declines in physical performance. This study examined whether pain severity mediates the association between depressive symptoms and physical performance in persons with radiographic knee OA.

Method

Three years of annual data from participants (n = 1,463) with radiographic knee OA in the Osteoarthritis Initiative (OAI) were analyzed. Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D) scale. Pain severity was evaluated with the Western Ontario and McMaster Universities Arthritis Index. Physical performance was assessed via standardized gait speed. Marginal structural models were used to assess the direct (unmediated) effects

SUBMITTER: Rathbun AM 

PROVIDER: S-EPMC6397771 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature