Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China.

ABSTRACT:

Background

Abnormal apoptosis of keratinocytes is one of the pathological changes of psoriasis. Caspases (CASPs) are the central engines of apoptosis. Studies to date have shown that some SNPs alter the expression of related genes and lead to changes in disease risk. However, no studies have investigated the associations between gene polymorphisms and the risk of psoriasis in Han population in northeast China. Therefore, we conducted a case-control study to explore this question in Han population of northeastern China.

Methods

540 patients with PsV and 612 healthy age- and sex-matched controls were enrolled in this study. We determined the genotypes of 17 single nucleotide polymorphisms (SNPs) from 11 genes of caspase family by the improved multiplex ligation detection react

SUBMITTER: Yao X 

PROVIDER: S-EPMC6398065 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature