Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy.

ABSTRACT:

Objective

To investigate the feasibility, safety, and tolerability of add-on treatment of the triglycerides of heptanoate (triheptanoin) vs the triglycerides of octanoate and decanoate (medium chain triglycerides [MCTs]) in adults with treatment-refractory epilepsy.

Methods

After an 8-week prospective baseline period, people with drug-resistant epilepsy were randomized in a double-blind fashion to receive triheptanoin or MCTs. Treatment was titrated over 3 weeks to a maximum of 100 mL/d to be distributed over 3 meals and mixed into food, followed by 12-week maintenance before tapering. The primary aims were to assess the following: (a) safety by comparing the number of intervention-related adverse events with triheptanoin vs MCT treatment and (b) adherence, measured as a per

SUBMITTER: Borges K 

PROVIDER: S-EPMC6398112 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature