Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors.

ABSTRACT:

Background

The current prognosis of thymic epithelial tumors (TETs) is according to the World Health Organization (WHO) histologic classification and the Masaoka staging system. These methods of prognosis have certain limitations in clinical application and there is a need to seek new method for determining the prognosis of patients with TETs. To date, there have been no studies done on the use of DNA methylation biomarkers for prognosis of TETs. The present study was therefore carried out to identify DNA methylation biomarkers that can determine the overall survival in patients with TETs.

Methods

Bioinformatic analysis of TCGA 450 K methylation array data, transcriptome sequencing data, WHO histologic classification and Masaoka staging system was performed to identify diffe

SUBMITTER: Li S 

PROVIDER: S-EPMC6398263 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature