Baseline Pupil Diameter Is Not a Reliable Biomarker of Subjective Sleepiness.

ABSTRACT: Sleepiness is commonly seen as reflecting the basic physiological need to sleep and is associated with physiological and neurobiological changes. Subjective evaluations of sleepiness, however, are neither representative of cognitive and physical performances, nor of physiological sleepiness. Finding a simple, rapid, and objective marker of sleepiness is essential in order to prevent errors and accidents, but this has remained largely unsuccessful. The aim of this study was to determine whether the baseline pupil diameter is a physiological biomarker of sleepiness at all times of day and to isolate the regulatory components involved. Twelve healthy men (20-29 years old) participated in a 56-h experimental protocol, including a 34-h constant routine paradigm with enforced wakefulness. This p

SUBMITTER: Daguet I 

PROVIDER: S-EPMC6398346 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature