Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice.

ABSTRACT:

Background

Menaquinone-4 (MK4), a vitamin K metabolite, is converted from phylloquinone through a process that requires intermediates of endogenous cholesterol production. Recent evidence suggests that MK4 is involved in kidney function.

Objective

The purpose of this study was to determine the effect of atorvastatin treatment on MK4 formation in young and old male mice.

Methods

C57BL/6 male mice (4-mo-old and 20-mo-old) were randomly assigned to either a diet containing 300 mg atorvastatin/kg with 3 mg phylloquinone/kg or a control diet containing 3 mg phylloquinone/kg for 8 wk. During week 8, all mice received deuterium-labeled phylloquinone in the diet. Labeled and unlabeled phylloquinone and MK4 in liver, kidney, brain, and intestine were measured by atmospheric pr

SUBMITTER: Harshman SG 

PROVIDER: S-EPMC6398385 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature