Prenatal Iron Deficiency and Replete Iron Status Are Associated with Adverse Birth Outcomes, but Associations Differ in Ghana and Malawi.

ABSTRACT:

Background

Previous literature suggests a U-shaped relation between hemoglobin concentration and adverse birth outcomes. There is less evidence on associations between iron status and birth outcomes.

Objective

Our objective was to determine the associations of maternal hemoglobin concentration and iron status with birth outcomes.

Methods

We conducted a secondary data analysis of data from 2 cohorts of pregnant women receiving iron-containing nutritional supplements (20-60 mg ferrous sulfate) in Ghana (n = 1137) and Malawi (n = 1243). Hemoglobin concentration and 2 markers of iron status [zinc protoporphyrin and soluble transferrin receptor (sTfR)] were measured at ≤20 weeks and 36 weeks of gestation. We used linear and Poisson regression models and birth outcomes incl

SUBMITTER: Oaks BM 

PROVIDER: S-EPMC6398386 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature