Reconstitution of immune cell interactions in free-standing membranes.

ABSTRACT: The spatiotemporal regulation of signalling proteins at the contacts formed between immune cells and their targets determines how and when immune responses begin and end. Therapeutic control of immune responses therefore relies on thorough elucidation of the molecular processes occurring at these interfaces. However, the detailed investigation of each component's contribution to the formation and regulation of the contact is hampered by the complexities of cell composition and architecture. Moreover, the transient nature of these interactions creates additional challenges, especially in the use of advanced imaging technology. One approach that circumvents these problems is to establish in vitro systems that faithfully mimic immune cell interactions, but allow complexity to be 'diall

SUBMITTER: Jenkins E 

PROVIDER: S-EPMC6398472 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature