Early detection of pre-malignant lesions in a KRAS^G12D-driven mouse lung cancer model by monitoring circulating free DNA.

ABSTRACT: Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies for the early detection of lung cancer are urgently sought. Total circulating free DNA (cfDNA) and tumour-derived circulating tumour DNA (ctDNA) are emerging as important biomarkers within a 'liquid biopsy' for monitoring human disease progression and response to therapy. Owing to the late clinical diagnosis of lung adenocarcinoma, the potential for cfDNA and ctDNA as early detection biomarkers remains unexplored. Here, using a Cre-regulated genetically engineered mouse model of lung adenocarcinoma development, driven by Kras^G12D (the Kras^LSL-G12D mouse), we serially tracked the release

SUBMITTER: Rakhit CP 

PROVIDER: S-EPMC6398498 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature