Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model.

ABSTRACT: Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic kras^G12V , we observed a progressive muscle-wasting phenotype in adult zebrafish, characterized by significant loss of body weight and muscle fibers. By differential feeding, we observed that overfeeding caused fatty liver, accelerated carcinogenesis and muscle wasting. Interestingly, leptin, an obesity hormone, was upregulated in oncogenic hepatocytes and overfeeding groups. We also found that leptin expression progressively increased during human liver disease progression. By using leptin receptor (lepr)-knockout fish, we found that tumor fish in the lepr

SUBMITTER: Yang Q 

PROVIDER: S-EPMC6398506 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature