Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity.

ABSTRACT: Reduced growth hormone (GH) signaling has been consistently associated with increased health and lifespan in various mouse models. Here, we assessed GH secretion and its control in relation with human familial longevity. We frequently sampled blood over 24 h in 19 middle-aged offspring of long-living families from the Leiden Longevity Study together with 18 of their partners as controls. Circulating GH concentrations were measured every 10 min and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) every 4 h. Using deconvolution analysis, we found that 24-h total GH secretion was 28% lower (P = 0.04) in offspring [172 (128-216) mU L^-1 ] compared with controls [238 (193-284) mU L^-1 ]. We used approximate entropy (ApEn) to quan

SUBMITTER: van der Spoel E 

PROVIDER: S-EPMC6398524 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature