A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR.

ABSTRACT: Longitudinal PET studies in aging and Alzheimer's disease populations rely on accurate and precise measurements of change over time from serial PET scans. Various methods for partial volume correction (PVC) are commonly applied to such studies, but existing comparisons and validations of these PVC methods have focused on cross-sectional measurements. Rate of change measurements inherently have smaller magnitudes than cross-sectional measurements, so levels of noise amplification due to PVC must be smaller, and it is necessary to re-evaluate methods in this context. Here we compare the relative precision in longitudinal measurements from serial amyloid PET scans when using geometric transfer matrix (GTM) PVC versus the traditional two-compartment (Meltzer-style), three-compartment (Müller-G

SUBMITTER: Schwarz CG 

PROVIDER: S-EPMC6398556 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature