Amygdalar activity predicts future incident diabetes independently of adiposity.

ABSTRACT: While it is established that psychosocial stress increases the risk of developing diabetes mellitus (DM), two key knowledge gaps remain: 1) the neurobiological mechanisms that are involved in mediating that risk, and 2) the role, if any, that adiposity plays in that mechanism. We tested the hypotheses that: 1) metabolic activity in the amygdala (AmygA), a key center involved in the neurobiological response to stress, associates with subsequent DM risk, and 2) this association is independent of adiposity. AmygA and adipose tissue volumes were measured, and serial blood assessments for DM were obtained in 232 subjects who underwent combined ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) imaging. Higher baseline AmygA predicted s

SUBMITTER: Osborne MT 

PROVIDER: S-EPMC6398601 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature