A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

ABSTRACT: Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (T_regs). However, this therapy has been limited by off-target complications due to pathogenic cell expansion. Recent efforts have been focused on developing a more selective IL-2. It is well documented that certain anti-mouse IL-2 antibodies induce conformational changes that result in selective targeting of T_regs. We report the generation of a fully human anti-IL-2 antibody, F5111.2, that stabilizes IL-2 in a conformation that results in the preferential STAT5 phosphorylation of T_regs in vitro and selective expansion of T_regs in vivo. When complexed with human IL-2, F5111.2 induced remission of type 1 diabetes in the NOD mouse model,

SUBMITTER: Trotta E 

PROVIDER: S-EPMC6398608 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature