Use of biologics during pregnancy and risk of serious infections in the mother and baby: a Canadian population-based cohort study.

ABSTRACT:

Objectives

To investigate the association between exposure to biologics during pregnancy and serious infections in mothers and infants.

Design

Retrospective cohort study.

Setting

Population-based.

Participants

Women with one or more autoimmune diseases identified by International Classification of Diseases 9th/10th revision codes in healthcare administrative databases in British Columbia, Canada, who had pregnancies ending in a live or stillbirth between 1 January 2002 and 31 December 2012. Women were defined as exposed if they had at least one biologic prescription during pregnancy, and infants born to these women were considered exposed in utero. Disease-matched women with no biologics prescriptions during pregnancy, and their infants, comprised the unexposed

SUBMITTER: Tsao NW 

PROVIDER: S-EPMC6398640 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature