Increased risk of bisphosphonate-related osteonecrosis of the jaw in patients with Sjogren's syndrome: nationwide population-based cohort study.

ABSTRACT:

Objective

The aim of this study was to explore whether patients with Sjögren's syndrome (SS) were susceptible to bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) after tooth extraction in the entire population of Taiwan.

Design

A nationwide population-based retrospective cohort study.

Setting

Data were extracted from Taiwan's National Health Insurance Research Database (NHIRD).

Methodology

Medical conditions for both the study and control group were categorised using the International Classification of Diseases, 9th Revision. ORs and 95% CIs for associations between SS and osteonecrosis of the jaw (ONJ) were estimated using Cox regression.

Results

Overall, 13 398 patients diagnosed with SS were identified from the NHIRD. An additional 53 592

SUBMITTER: Liao MT 

PROVIDER: S-EPMC6398708 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature