Association between statin use and herpes zoster: systematic review and meta-analysis.

ABSTRACT:

Objective

Statins are commonly prescribed worldwide. In addition to being potent lipid-lowering agents, statins have immunomodulating properties that may increase the risk of varicella zoster virus reactivation. This adverse effect may have substantial public health implications.

Design

We performed a meta-analysis of observational studies to assess the association between statin use and the risk of herpes zoster infection. We searched PubMed, Embase, Web of Science and Cochrane databases to identify studies published from 1980 to 2018. The multivariate-adjusted ORs were pooled using random-effect models, and subgroup and sensitivity analyses were performed to examine the source of heterogeneity.

Result

Six studies were analysed, with a total of more than two million

SUBMITTER: Fan L 

PROVIDER: S-EPMC6398719 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature