Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

ABSTRACT:

Introduction

Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Anecdotal evidence suggests that topical TXA may be of value in persistent epistaxis; however, further evaluation is required.

Methods and analysis

This is a multicentre, double-blind, parallel group, randomised, controlled trial comparing the use of topical intranas

SUBMITTER: Reuben A 

PROVIDER: S-EPMC6398761 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature