Convergent microstructural brain changes across genetic models of autism spectrum disorder-A pilot study.

ABSTRACT: Autism spectrum disorder (ASD) is a complex and genetically heterogeneous neuropsychiatric disease affecting as many as 1 in 68 children. Large scale genetic sequencing of individuals along the autism spectrum has uncovered several genetic risk factors for ASD; however, understanding how, and to what extent, individual genes contribute to the overall disease phenotype remains unclear. Neuroimaging studies of ASD have revealed a wide spectrum of structural and functional perturbations that are thought to reflect, in part, the complex genetic heterogeneity underpinning ASD. These perturbations, in both preclinical models and clinical patients, were identified in preclinical genetic models and ASD patients when compared to control populations; however, few studies have directly explored intri

SUBMITTER: Rowley PA 

PROVIDER: S-EPMC6398946 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature