Associations between baseline biomarkers and lung function in HIV-positive individuals.

ABSTRACT:

Objective

The aim of this study was to analyse the association of baseline biomarker data with cross-sectional lung function and subsequent decline in lung function in HIV-positive persons.

Design

Lung function was modelled in all START pulmonary substudy participants who had baseline biomarker data and good-quality spirometry. In longitudinal analyses, we restricted to those participants with at least one good-quality follow-up spirometry test.

Methods

We performed linear regression of baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC and their longitudinal slopes on log2-transformed baseline biomarkers with adjustment for age, sex, race, region, smoking status, baseline CD4+ T-cell counts and baseline HIV-RNA. Biomarkers inclu

SUBMITTER: MacDonald DM 

PROVIDER: S-EPMC6399058 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature