Genomics of Reproductive Traits and Cardiometabolic Disease Risk in African American Women.

ABSTRACT:

Background

Age at menarche and age at natural menopause occur significantly earlier in African American women than in other ethnic groups. African American women also have twice the prevalence of cardiometabolic disorders related to the timing of these reproductive traits.

Objectives

The objectives of this integrative review were to (a) summarize the genome-wide association studies of reproductive traits in African American women, (b) identify genes that overlap with reproductive traits and cardiometabolic risk factors in African American women, and (c) propose biological mechanisms explaining the link between reproductive traits and cardiometabolic risk factors.

Methods

PubMed was searched for genome-wide association studies of genes associated with reproductive trai

SUBMITTER: Hardy TM 

PROVIDER: S-EPMC6399059 | biostudies-literature | 2019 Mar/Apr

REPOSITORIES: biostudies-literature