Pharmacogenomics of Multiple Sclerosis: A Systematic Review.

ABSTRACT: Background: Over the past two decades, various novel disease-modifying drugs for multiple sclerosis (MS) have been approved. However, there is high variability in the patient response to the available medications, which is hypothesized to be partly attributed to genetics. Objectives: To conduct a systematic review of the current literature on the pharmacogenomics of MS therapy. Methods: A systematic literature search was conducted using PubMed/MEDLINE database searching for articles investigating a role of genetic variation in response to disease-modifying MS treatments, published in the English language up to October 9th, 2018. PRISMA guidelines for systematic reviews were applied. Studies were included if they investigated response or nonresponse to MS treatment defi

SUBMITTER: Hocevar K 

PROVIDER: S-EPMC6399303 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature