Incidence of new-onset diabetes mellitus and association with mortality in childhood solid organ transplant recipients: a population-based study.

ABSTRACT:

Background

Precise estimates of the long-term risk of new-onset diabetes and its impact on mortality among transplanted children are not known.

Methods

We conducted a cohort study comparing children undergoing solid organ (kidney, heart, liver, lung and multiple organ) transplant (n = 1020) between 1991 and 2014 with healthy non-transplanted children (n = 7 134 067) using Ontario health administrative data. Outcomes included incidence of diabetes among transplanted and non-transplanted children, the relative hazard of diabetes among solid organ transplant recipients, overall and at specific intervals posttransplant, and mortality among diabetic transplant recipients.

Results

During 56 019 824 person-years of follow-up, the incidence rate of diabetes was 17.8 [95% conf

SUBMITTER: Chanchlani R 

PROVIDER: S-EPMC6399486 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature