Hybrid Sterility with Meiotic Metaphase Arrest in Intersubspecific Mouse Crosses.

ABSTRACT: Although organisms belonging to different species and subspecies sometimes produce fertile offspring, a hallmark of the speciation process is reproductive isolation, characterized by hybrid sterility (HS) due to failure in gametogenesis. In mammals, HS is usually exhibited by males, the heterogametic sex. The phenotypic manifestations of HS are complex. The most frequently observed are abnormalities in both autosomal and sex chromosome interactions that are linked to meiotic prophase arrest or postmeiotic spermiogenesis aberrations and lead to defective or absent gametes. The aim of this study was to determine the HS phenotypes in intersubspecific F1 mice produced by matings between Mus musculus molossinus-derived strains and diverse Mus musculus domesticus-inbred laboratory mouse strains.

SUBMITTER: Nishino R 

PROVIDER: S-EPMC6399516 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature